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The composite results suggest the presence of increased production and release of dopamine a malfunction of the receptors that bind the dopamine and transmit the dopamine signal to other cells.The increase in dopamine may be the brain cells' response to the poor signal.
In the last 20 years, there has been a substantial amount of research into understanding the cause of RLS.
From that research there appears to be three factors which are pertinent to the disease: brain concentrations of iron, brain dopamine concentrations and genes.
They also may occur when someone is inactive and sitting for extended periods (for example, when taking a trip by plane or watching a movie).
What is the prognosis for people with restless legs syndrome? Symptoms commonly occur in the late afternoon or evening hours, and are often most severe at night when a person is resting, such as sitting or lying in bed.
RLS is also related to environmental factors and genes.
The single largest known environmental factor is low iron levels, which may occur before birth, during infancy or childhood, during pregnancy or later in adult life.
Despite this strong association between serum iron insufficiency and RLS, only about 15% of the RLS clinical population appears to have peripheral iron deficiency (serum ferritin .
Despite the substantial body of research on peripheral iron regulation, we still know very little about how iron is regulated by the blood-brain barrier or by the different cells within the brain.
The key question is the impact of the RLS-risk genes' variations on cell metabolism iron management and the iron-dopamine relationship.Tags: Adult Dating, affair dating, sex dating